Sprague Dawley rat hepatocytes (TRL)
- Rat hepatocytes from Sprague Dawley rats
- Fresh and cryopreserved formats
- High viability (>80%)
- Characterized for Phase I/II drug-metabolizing enzyme activity
- Characterized for plateability
Rat hepatocytes are isolated by Triangle Research Laboratories (now part of Lonza) and characterized for viability, plateability (adherence to a collagen-coated surface), and general Phase I and Phase II drug metabolizing enzyme activities.
Rat hepatocytes from Sprague Dawley rats are available in cryopreserved and fresh format. Fresh rat hepatocytes are also available plated in a monolayer.
Cryopreserved rat hepatocyes viability
Suspension qualified cryopreserved rat hepatocytes have post-thaw viabilities over 80%.
Plateable cryopreserved rat hepatocytes have post-thaw viabilities over 80%. Each lot can also be plated in a collagen-coated plate or similar. These lots are guaranteed to maintain a healthy monolayer (>85% confluency) for a minimum of 3 days in culture.
Fresh rat hepatocyes viability
Each lot of fresh hepatocytes is tested before release to ensure that hepatocytes are high viability. The fresh hepatocytes in suspension are at least 80% viable and plated hepatocyte monolayers are at least 85% confluent.