Serum-free cell cullture: get rid of serum issues

To keep cells in culture alive and kicking, standard cell culture is performed with the addition of 5-10% of bovine or fetal calf serum (FBS and FCS, respectively). However, serum has various disadvantages for your cell culture as it can affect the consistency, and reproducibility, of your results*.

Get reproducible results with serum-free cell culture

Gain control over your culture conditions and choose to switch to a serum-free medium that works best for your type of cells. Our serum-free media are chemically defined, so you know what's in there! If you rather like to keep on using your current cell culture medium, you can also choose to replace your FBS/FCS with our HL-1 supplement.

HL-1 FBS/FCS Substitute

Our HL-1 Chemically Defined FBS substitute contains no bovine serum albumin or other undefined protein mixtures. You can replace your fetal serum with HL-1, as it supports the growth of various cell types.

  • Chemically Defined FBS/FCS alternative
  • No more batch testing
  • No risk of pathogens or other contaminants
  • Defined low protein concentrations <30µg/ml
  • Supports growth of various cell types

UltraMEM Reduced Serum medium

For general cell culture conditions, in which you still need a reduced amount of serum, you can choose our UltraMEM medium to get those reproducible results.

  • Chemically defined medium with reduced serum concentrations
  • Weaning of cells unnecessary
  • Low protein concentration (20 μg/ml)
  • Maintain confluent cultures with 0-1% serum
  • Exceeds growth performance when cultured in 10% FBS

UltraCulture All Purpose Medium

When culturing specific cell types that need more attention, you can choose our UltraCULTURE medium that's appropriate and optimized for many cell types.

  • DMEM:F12 medium with low protein concentration (3 mg/ml)
  • Intended for adherent and non-adherent cells
  • Can be used for generation of virus particles
  • Supports cell fusion during hybridoma generation
Contact us to help you choose your serum-free media

* Serum can affect the consistency, and reproducibility, of your results:

  • It contains numerous undefined factors

  • It has a high lot-to-lot variability

  • It has a high risk of contamination with infectious agents

  • It has a high risk of contamination with other interfering components

Due to these disadvantages, your cells can respond differently when compared to the exact same cells other groups are culturing. Differences can even occur in your own experiments due to serum batch variability, leaving you, as said, with non-reproducible results.